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Rad51 Polyclonal Antibody

Rad51 Polyclonal Antibody

简要描述:Rad51 Polyclonal Antibody
宿主: Polyclonal, Rabbit,IgG
反应性: Human;Mouse
应用: WB;IHC;IF;ELISA

产品型号: YP-Ab-00510

所属分类:多克隆抗体

更新时间:2023-11-01

详细说明:

Rad51 Polyclonal Antibody

抗体,也叫免疫球蛋白(Ig),是一种能特异性结合抗原的糖蛋白,而抗原是在易感染动物体内引发抗体产生的物质。在体内,抗体是由于外源性分子的侵袭而产生的。抗体以一个或者多个Y字形单体存在,每个Y字形单体由4条多肽链组成,包含两条相同的重链和两条相同的轻链。轻链和重链是根据它们的分子量大小来命名的。Y字形结构的顶端是可变区,为抗原结合部位。任何一个抗体的轻链都可以分为κ或λ型(基于小分子多肽结构上的差异),每一个抗体的重链则决定了它的类或型。

产品详情
Rad51 Polyclonal Antibody detects endogenous levels of Rad51 protein.
免疫原详细信息
The antiserum was produced against synthesized peptide derived from human RAD51. AA range:281-330
相关试剂
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
背景

The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]


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备注:图片仅供参考。仅供科研,不可用于临床。

Rad51D Polyclonal Antibody




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